Lapis ISSN 2398-2969

Serum fructosamine

Contributor(s): Vetstream Ltd, Jenna Richardson


  • Glycosylated protein complexes.
  • Forms in blood in a non-enzymic, non-insulin-dependent manner.
  • [Fructosamine] proportional to [glucose]   Blood biochemistry: glucose   over life-span of protein - mostly albumin (1-2 weeks).
  • Used to identify long-term presence of hyperglycemia.
  • Less affected by short-term factors: stress, feeding, exercise.
  • Useful in prey animals where handling alone can give falsely elevated blood glucose measurements.


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  • Photometric (colorimetric) method based on the ability of ketoamines to reduce nitroblue tetrazolium (NBT) to formazan in an alkaline medium.


  • Available in most commercial laboratories.



  • Good sensitivity for glycosylated proteins.


  • Color may be generated by compounds other than glycosylated proteins, eg elevated bilirubin values. This may result in falsely elevated values. Second generation assays, if used, are highly specific for glycosylated proteins.

Predictive value

  • A diagnosis of diabetes mellitus should not be based entirely on fructosamine values.
  • Clinical signs, repeat urinalysis and blood glucose   Blood biochemistry: glucose  values should also be taken into consideration.

Result Data

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Further Reading


Refereed papers

  • Conaway H H, Faas F H, Smith S D & Saunders L L (1981) Spontaneous diabetes mellitus in the New Zealand white rabbit: physiological characteristics. Metabolism30(1), 50-56PubMed.

Other sources of information

  • Harpole T, Runyeard V, English K & Archer J (2002)Serum Fructosamine in Hyperglycaemic Rabbits.In: 12th ECVIM-CA/ESVIM Congress.
  • Holloway H K R & Carmichael N G (2001)Significance of Serum Fructosamine in Rabbits.In: BSAVA Congress, Birmingham, UK.


  • Idexx Laboratories, PO Box 4, Wetherby, West Yorkshire LS22 4ZR, UK.
  • Pinmoore Animal Laboratory Services, The Coach House, Town House Barn, Tarporley Road, Clotton, Tarporley, Cheshire CW6 0EG, UK.