Lapis ISSN 2398-2969

Blood biochemistry: creatine phosphokinase

Synonym(s): CPK, CK, Creatinine kinase

Contributor(s): Vetstream Ltd, Vicki Baldrey

Overview

  • Occurs as 3 isoenzymes in skeletal muscle, cardiac muscle and central nervous system (CNS):
    • CK1 (BB) in brain, peripheral nerve, cerebrospinal fluid and viscera. Not found in serum.
    • CK2 (MB) in cardiac muscle, with very small amounts in skeletal muscle.
    • CK3 (MM) in skeletal and cardiac muscle.
  • Most sensitive indicator of muscle damage.
  • Half-life 2-4 h.
  • Levels peak 6-12 h post-injury, returning to normal in 2-3 days after cessation of injury.
  • Persistent elevation indicates continuing or active disease.

Sampling

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Tests

Methodologies

  • Methods (and reference interval) vary between laboratories.
  • Enzymatic/spectrophotometric measurement.

Availability

  • Widely available at commercial laboratories.

Result Data

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Jenkins J R (2008) Rabbit diagnostic testing. J Exot Pet Med 17 (1), 4-15 VetMedResource.
  • Melillo A (2007) Rabbit clinical pathology. J Exot Pet Med 16 (3), 135-145 JExotPetMed.

Other sources of information

  • Wesche P (2014) Clinical Pathology. In: Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA. pp 124-137.
  • Saunders R & Rees Davies R (2005) Common Laboratory Abnormalities. In: Notes on Rabbit Internal Medicine. Blackwell Publishing, Oxford. pp 69-88.


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