Lapis ISSN 2398-2969

Blood biochemistry: alkaline phosphatase

Synonym(s): ALP, Serum alkaline phosphatase, SAP

Contributor(s): Michael Waters, Anna Meredith, Vetstream Ltd, John Chitty

Overview

  • Number of isoenzymes produced in a range of tissues. Rabbits have two liver and kidney ALP isoenzymes. There is an additional isoenzyme from gut.
  • Increased plasma levels are derived from liver and bone and intestine. Also found in pregnant does originating from placenta (plasma ALKP levels fall in pregnancy).
  • Good indicator of cholestasis - increases before plasma bilirubin.
  • Non-specific for liver disease as may rise in extra-hepatic cholestasis, bone disease/fractures, intestinal disease.

Sampling

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Tests

Methodologies

  • Method and normal range may vary between laboratories.
  • Electrophoretic or other separation method necessary to measure activity of individual isoenzymes.

Availability

  • Routine test.

Technique (intrinsic) limitations

  • Test results most significant when interpreted in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedandVetMedResource
  • Meredith A & Rayment L (2000)Liver disease in rabbits. Sem Avian Exotic PetMed9(3), 146-152.
  • Benson K G & Paul-Murphy J (1999)Clinical pathology of the domestic rabbit: acquisition and interpretation of samples. Vet Clin North Am Exotic Anim Pract2(3), 539-552PubMed.

Other sources of information

  • Bourne D (2016)Clinical Pathology of Lagomorphs. In:  Wildpro.Website:http://wildpro.twycrosszoo.org/S/00Man/LagomorphOverviews/Clinical%20Pathology_Rabbits.htm.
  • Wesche P (2014)Clinical Pathology.In: BSAVA Manual of Rabbit Medicine.Eds: Meredith A & Lord B. BSAVA, Gloucester, UK. pp 124-137.
  • Varga M (2014)Laboratory Medicine. Avian and Exotic Pets.W B Saunders Co. ISBN: 0721676790.
  • Fudge A M (1999)Laboratory Medicine. Avian and Exotic Pets.W B Saunders Co. ISBN: 0721676790.


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