Lapis ISSN 2398-2969

Vitamin E

Synonym(s): Alpha-tocopherol

Contributor(s): Molly Varga, Anna Meredith

Introduction

Name

  • Alpha-tocopherol.

Class of drug

  • Vitamin.

Description

Chemical name

  • (+)-2,5,7,8-tetramethyl-2-(4812-trimethyltridecyl)-6-chromanol.

Molecular formula

  • C29H50O2.

Molecular weight

  • 430.69.

Physical properties

  • Water insoluble pale viscous oil.
  • Boiling point 210degC.
  • Melting point 2-3degC.

Storage requirements

  • Alpha-tocopherol is destroyed by light and oxygen, but is relatively heat stable.
  • Viability is lost during significant heating and freezing.
  • Encapsulation protects against vitamin E destruction.

Uses

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Indications

  • Vitamin E deficiency   Hypovitaminosis E  .
  • Vitamin E is indicated for the treatment of nutritional muscular dystrophy   Nutrition: muscular dystrophy  in young rabbits.
  • Also used as a topical anti-inflammatory agent.
  • May improve reproductive efficiency by reducing germ cell oxidative damage.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with diagnostic tests

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Castellini C, Mourvaki E, Dal Bosco A et al (2007) Vitamin E biochemistry and function: A case study in male rabbit. Reprod Dom Anim 42 (3), 248-256 PubMed.
  • Czarnecki W & Zimmer L (2006) Pharmacokinetics and bioavailability of alpha-tocopherol in rabbits. Annales Universitatis Mariae Curie-Skladowska Lublin-Polonia 19 (2, 22), 153-160.
  • Schneider C (2005) Chemistry and biology of vitamin E. Mol Nutr Food Res 49 (1), 7-30 PubMed.
  • St Clair M B, Kennett M J & Besch-Williford C L (2004) Vitamin A toxicity and vitamin E deficiency in a rabbit colony. Contemp Top Lab Anim Sci 43 (4), 26-30 PubMed.
  • Axford-Gatley R A & Wilson G J (1990) Reduction of experimental myocardial infarct size by oral administration of alpha-tocopherol. Cardiovasc Res 25 (2), 89-92 PubMed.
  • Godfried S L, Combs G F Jr., Saroka G M et al (1989) Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E. Br J Nutr 61 (3), 607-617 PubMed.
  • Bardosi A & Dickmann U (1987) Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E. Acta Neuropathologica 75 (2), 166-172 PubMed.
  • Jack Yang N Y & Desai I D (1976) Effect of high levels of dietary vitamin E on hematological indices and biochemical parameters in rats. J Nutr 107 (8), 1410-1417 PubMed.
  • March B E, Wong E, Seier L et al (1972) Hypervitaminosis E in the chick. J Nutr 103 (3), 371-377 PubMed.

Other sources of information

  • Higdon J, Drake V J & Traber M G (2008) Vitamin E. Oregon State University, Linus Pauling Institute, Micronutrient Information Center. Website:http://lpi.oregonstate.edu/infocenter/vitamins/vitaminE
  • Higdon J, Drake V J & Russell R M (2007) Vitamin A. Oregon State University, Linus Pauling Institute, Micronutrient Information Center. Website:http://lpi.oregonstate.edu/infocenter/vitamins/vitaminA
  • Harcourt-Brown F (2002) Textbook of Rabbit Medicine. Butterworth Heinemann.
  • Lowe J A (1998) Pet Rabbit Feeding and Nutrition. In:The Nutrition of The Rabbit. Eds: de Blas C & Wiseman J. pp 309-332 CABI Publishing.
  • McDonald P, Edwards R A, Greenhalgh J F D & Morgan C A (1996) Animal Nutrition. 5th edn. Longman.
  • Cheeke P R (1994) Nutrition and Nutritional diseases. In:The Biology of the Laboratory Rabbit.2nd edn. Eds: Manning  P J, Ringler D H & Newcomer C E. Academic Press. pp 321-333.
  • Hunt C E & Harrington D D (1974) Nutrition and Nutritional diseases of the Rabbit. In:The Biology of the Laboratory Rabbit. 1st edn. Eds: Manning P J, Ringler D H & Newcomer C E. Academic Press. pp 403-428.
  • The British National Formulary. Website:www.BNF.org.uk.

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