Lapis ISSN 2398-2969

Tropicamide

Synonym(s): Mydriacyl

Contributor(s): Lesa Thompson, Anna Meredith

Introduction

Name

  • Tropicamide.

Class of drug

  • Anticholinergic.

Description

Chemical name

  • Tropicamide.
  • (2RS)N-ethyl-3-hydroxy-2-phenyl-N-(prid-4-ylmethyl)propionamide.

Molecular formula

  • C 17 H 20 N 2 O 2 .

Molecular weight

  • 284.35.

Physical properties

  • Sterile ophthalmic solution.
  • Preserved with benzalkonium chloride   Benzalkonium chloride  .
  • 0.5% (5 mg/ml) or 1% (10 mg/ml) concentrations available.

Storage requirements

  • To reduce risk of bottle contamination, do not touch dropper bottle to ocular surface during application.
  • Discard drops within 28 days of opening.

Uses

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Indications

  • Ophthalmic examination (particularly of the fundus)   Ophthalmic examination  .
  • Useful in rabbits since many have atropinesterase.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Potential interactions with concomitant use of other antimuscarinic drugs, eg some antihistamines.

with diagnostic tests

  • Unable to assess iris after mydriasis performed.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Harcourt-Brown F (2002) The Rabbit Consultation and Clinical techniques. In:Textbook of Rabbit Medicine. Oxford. pp 52-93.
  • Harkness J E & Wagner J E (1995) The Biology and Medicine of Rabbits and Rodents. 4th edn. Williams & Wilkins, Media, PA.
  • Product Information -Mydriacyl ® (Tropicamide) 0.5% and 1.0% Eye Drops. In:Medsafe - New Zealand Medicines and Medical Devices Safety Authority. Website:www.medsafe.govt.nz/Profs/Datasheet/m/Mydriacyleyedrop.pdf. Last accessed 29th October 2012.

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