Lapis ISSN 2398-2969

Tetracycline

Contributor(s): Anna Meredith

Introduction

Name

  • Tetracycline.

Class of drug

  • Tetracycline antibiotic.

Uses

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Indications

  • A bacteriostatic antibiotic which inhibits the growth of many gram-positive and gram-negative bacteria, several rickettsiae, mycoplasma, spirochaetes (Lyme disease) and other microbes.
  • Tetracycline differs from oxytetracycline   Oxytetracycline  in its lipid solubility (oxytetracycline low solubility, tetracycline intermediate solubility) although this is unlikely to be of clinical relevance.
  • Ophthalmic tetracycline is the preferred agent for the treatment of chlamydia, mycoplasma or rickettsial eye infections.
  • Tetracycline is also used to cause pleurodesis.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Penicillins
  • The bactericidal action of the penicillins may be inhibited by bacteriostatic antibiotics.

Drugs inhibiting absorption of orally administered tetracyclines

  • Antacids containing divalent or trivalent cations (magnesium, calcium, aluminium).
  • Iron.
  • Oral sodium bicarbonate.

Digoxin

  • The bioavailability of digoxin may be increased by tetracyclines for months after their discontinuation. This may lead to digoxin toxicity.

Anticoagulants

  • Plasma prothrombin activity may be decreased by tetracyclines and therefore patients on anticoagulant therapy may need a dose adjustment.

Methoxyflurane

  • Tetracyclines may increase the nephrotoxic effects of methoxyflurane.

Theophyllines

  • The gastrointestinal (GI) effects of tetracyclines may be increased.

with diagnostic tests

  • Plasma prothrombin activity may be decreased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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