Lapis ISSN 2398-2969

Neomycin

Contributor(s): Jill Pearson

Introduction

Name

  • Neomycin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • Gram-negative infections.
  • Some staphylococcal and streptococcal (fecalis) infections.
    All obligate anaerobic bacteria and many hemolytic streptococci are resistant
  • As neomycin is extremely nephrotoxic and ototoxic it is:
    • Primarily used topically for infections of skin, ear or mucous membranes, or orally to reduce intestinal bacterial population before intestinal surgery.
    • Non-specific bacterial enteritides - often in combination with antimuscarinic agents.

    This dosage regimen is derived from human data

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Drugs affected by neomycin (decreased absorption)
  • Digoxin.
  • Methotrexate.
  • Penicillin V.
  • Potassium.
  • Vitamin K.

Ototoxic and nephrotoxic drugs, eg frusemide, gentamicin and polymyxin B

  • Increased risk of toxicity.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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