Lapis ISSN 2398-2969

Naloxone

Contributor(s): Molly Varga, Jill Pearson

Introduction

Name

  • Naloxone.

Class of drug

  • Opioid antagonist (pure antagonist, no agonist properties at all).

Description

Chemical name

  • (1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one.

Molecular formula

  • C19H21NO4.

Molecular weight

  • 327.37.

Uses

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Indications

  • Indicated for treatment of gross overdosage of all narcotic including agonist/antagonists, eg butorphanol   Butorphanol  , nalbuphine   Nalbuphine  .
  • Has been used in the management of shock (high doses).
  • To identify persistent opioid activity (a small IV dose will give transient increase in consciousness when persistent opioid activity contributes to prolonged anesthetic recovery).

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Narcotics
  • The narcotic effects may persist longer than that of naloxone, therefore monitor animals being treated for overdose carefully, until the narcotic effects remain negated.
  • Naloxone will also reverse the analgesic effects of narcotics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

Organisation(s)


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