ISSN 2398-2969      

Nalbuphine

Clapis
Contributor(s):

Molly Varga

Anna Meredith


Introduction

Name

  • Nalbuphine.

Class of drug

  • Opioid analgesic.
  • Opioid reversal agent.
  • Opioid agonist/antagonist.

Description

Chemical name

  • ()-17-(cyclobutylmethyl)- 4,5alpha-epoxymorphinan-3,6alpha,14-triol hydrochloride.

Molecular formula

  • C21H27NO4.

Molecular weight

  • 357.44.

Uses

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Indications

  • Analgesia.
  • Narcotic reversal agent.
  • Antagonization of some of the adverse effects of pre-administered opioid agonists without complete reversal of analgesia (sequential analgesia).

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Barbiturate anesthetics, phenothiazines and tranquilizers
  • May enhance nalbuphine's respiratory and central nervous depression.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website:www.gov.uk/government/collections/veterinary-medicines-guidance-notes-vmgns.
  • Hawk C T & Leary S (1995) Formulary for Laboratory Animals. Compiled in association with ACLAM (1995). Iowa State University Press, Ames.

Organisation(s)

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