Lapis ISSN 2398-2969

Mupirocin

Synonym(s): Pseudominic acid

Introduction

Name

  • Mupirocin.

Class of drug

  • Antibacterial agent.

Description

Chemical name

  • [2S-[2alpha(E),3beta,4beta,5alpha[2R*,3R*(1R*,2R*)]]]-9-[[3-methyl-1-oxo-4-[tetrahydro-3,4-dihydroxy-5-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-2H-pyran-2-yl]-2-butenyl]oxy]nonanoic acid.

Molecular formula

  • C26H44O9.

Molecular weight

  • 500.63.

Physical properties

  • Crystalline.

Uses

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Indications

  • Bacterial skin infections.

Administration

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Precautions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Harbarth S, Dharan S, Liassine N et al (1999) Randomized, placebo-controlled, double-blind trial to evaulate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 43 (6), 1412-1416 PubMed.
  • Williford P M (1999) Opportunities for mupirocin calcium cream in the emergency department. J Emerg Med 17 (1), 213-220 PubMed.
  • Cookson B D (1998) The emergence of mupirocin resistance - a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother 41 (1), 11-18 PubMed.
  • Riu S, Ruiz C G, Martinez-Vea A et al (1998) Spontaneous rupture of polyurethane peritoneal catheter. A possible deleterious effect of mupirocin ointment. Nephrol Dial Transplant 13 (7), 1870-1871 PubMed.
  • Goldfarb J (1995) New antimicrobial agents. Pediatr Clin North Am 42 (3), 717-735 PubMed.
  • Vizcaino-Alcaide M J, Herruzo-Cabrera R, Rey-Calero J et al (1993) Efficacy of a broad-spectrum antibiotic (mupirocin) in an in vitro model of infected skin. Burns 19 (5), 392-395 PubMed.
  • Czarnecki D, Meehan C, Nash C (1992) Prevention of post-excisional wound infections - a comparison of oral cephalexin with topical mupirocin and topical cetrimide-chlorhexidine cream. Int J Dermatol 31 (5), 359-360 PubMed.
  • Leyden J J (1992) Review of mupirocin ointment in the treatment of impetigo. Clin Pediatr (Phila) 31 (9), 549-553 PubMed.
  • Johnston C (1991) Topical 2% mupirocin versus 2% sodium fusidate ointment in the treatment of primary and secondary skin infections. J Am Acad Dermatol 24 (5 Part 1), 797-798 PubMed.
  • Lamb Y J (1991) Overview of the role of mupirocin. J Hosp Infect 19 (Suppl B), 27-30 PubMed.

Other sources of information

  • Tennant B (1999) Small Animal Formulary. 3rd edn. British Small Animal Veterinary Association. ISBN 0 905214 52 8.

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