Lapis ISSN 2398-2969

Morphine

Contributor(s): Molly Varga, Jill Pearson

Introduction

Name

  • Morphine.

Class of drug

  • Opioid analgesic.

Description

Chemical name

  • (5alpha,6alpha)-7,8-didehydro- 4,5-epoxy-17-methylmorphinan-3,6-diol.

Molecular formula

  • C17H19NO3.

Storage requirements

  • Must be stored in a locked safe and its use recorded in a logbook.

Uses

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Indications

  • A narcotic analgesic used primarily as a pre-anesthetic agent   Anesthesia: preparation  .
  • Peri-operative and severe traumatic pain relief   Analgesia  .
  • Extradural analgesia.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

CNS depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers)
  • Enhanced central nervous system (CNS) or respiratory depression may occur.

with diagnostic tests

Plasma amylase or lipase
  • As narcotic analgesics can increase biliary tract pressure, levels may be increased for up to 24 hours after drug administration.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Navarrete-Calvo R, Gómez-Villamandos R J, Morgaz J et al (2014) Cardiorespiratory, anaesthetic and recovery effects of morphine combined with medetomidine and alfaxalone in rabbits. Vet Rec 174 (4), 95 PubMed.

Other sources of information

Organisation(s)


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