Lapis ISSN 2398-2969

Metronidazole

Contributor(s): Jill Pearson

Introduction

Name

  • Metronidazole.

Class of drug

  • Synthetic nitroimidazole.

Uses

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Indications

  • Anerobic infections, egBacteroidesspp,Clostridiumspp   Clostridium difficile  etc, giardiasis and other protozoal infections.
  • Adjunct to treatment of pyothorax.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Phenobarbitone or phenytoin
  • May increase metabolism of metronidazole.

Cimetidine

  • May decrease metabolism of metronidazole and increase the likelihood of dose-related adverse effects occurring.

with diagnostic tests

  • The one-stage prothrombin (OSPT) time in patients on warfarin may be prolonged by metronidazole.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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