Lapis ISSN 2398-2969

Medetomidine

Contributor(s): Molly Varga, Jill Pearson

Introduction

Name

  • Medetomidine.

Class of drug

  • Alpha-2 adrenergic agonist.

Description

Chemical name

  • (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole.

Molecular formula

  • Cl3H16N2.

Molecular weight

  • 200.28.

Uses

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Indications

  • To provide sedation   Sedation  and analgesia   Analgesia  .
  • Good visceral analgesia.
  • Has very potent anesthetic-sparing properties when used as a premedicant   Anesthesia: preparation  .
  • It counteracts muscle rigidity associated with 'dissociative anesthesia' (ketamine   Ketamine  ).
  • It may be used in conjunction with acepromazine   Acepromazine maleate  and opioids   Morphine  to improve the effect of chemical restraint.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not use in patients receiving sympathomimetic amines.

with diagnostic tests

  • Causes a transient increase in blood glucose, so affects blood glucose determinations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Navarrete-Calvo R, Gómez-Villamandos R J, Morgaz J et al (2014) Cardiorespiratory, anaesthetic and recovery effects of morphine combined with medetomidine and alfaxalone in rabbits. Vet Rec 174 (4), 95 PubMed.
  • Orr H E, Roughan J V & Flecknell P A (2005) Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit. Vet Anaesth Analg 32 (5), 271-279 PubMed.
  • Difilippo S M, Norberg P J, Suson U D et al (2004) A comparison of xylazine and medetomidine in an anesthetic combination in New Zealand White Rabbits. Contemp Top Lab Anim Sci 43 (1), 32-34 PubMed.
  • Flecknell P A & Liles J H (1996) Halothane anaesthesia in the rabbit - a comparison of the effects of medetomidine, acepromazine and midazolam on breath-holding during induction. J Ass Vet Anaesth 23 (1), 11-14 VetMedResource.

Other sources of information

Organisation(s)


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