Lapis ISSN 2398-2969

Marbofloxacin

Introduction

Name

  • Marbofloxacin

Class of drug

  • Antibiotic.
  • Fluoroquinolone.

Uses

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Indications

Infections
  • Effective against mycoplasmas and many gram-positive and gram-negative organisms includingPasteurellaspp,Staphylococcusspp,Pseudomonas aeruginosa, Klebsiellaspp,Escherichia coli, Proteusspp andSalmonellaspp.
  • Aerobic.
  • Ineffective against anaerobic infections.
  • Fluoroquinones are highly lipophilic and atain high concentrations within cells in many tissues.
  • Particularly effective in soft tissue, urogenital (including prostatitis) and skin infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adsorbents and antacids
  • Containing cations (Mg, Al) may bind to fluoroquinolones and prevent their absorption from the GIT.

Theophylline

  • Fluoroquinolones increase plasma theophylline concentrations.

Probenecid

  • Blocks the tubular secretion of fluoroquinolones and may increase their blood level and half-life.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Scneider M, Valle M, Woehrle F & Boisrame B (2001) Pharmacokinetic/pharmacodynamic parameters of marbofloxacin in rabbits. Clinical Abstract presented at BSAVA Congress, Birmingham.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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