Lapis ISSN 2398-2969

Lidocaine

Synonym(s): Lignocaine

Contributor(s): Vetstream Ltd, Jill Pearson, Molly Varga

Introduction

Name

  • Lidocaine.

Class of drug

  • Amide-linked local anesthetic.
  • Class 1B antidysrhythmic.

Description

Chemical name

  • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide.

Molecular formula

  • C14H22N2O.

Molecular weight

  • 234.34.

Uses

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Indications

  • Drug of choice for treating acute ventricular dysrhythmias.
  • Used predominantly as a local anesthetic   Anesthesia: overview  .

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Cimetidine
  • May increase serum lidocaine levels or its effects if administered concurrently.

Propranolol

  • May increase serum lidocaine levels or its effects if administered concurrently.

Procainamide

  • May cause additive CNS effects.

Other anti-dysrhythmics

  • May cause increased myocardial depression.

Acetazolamide, loop diuretics and thiazides

  • The effect of lidocaine may be antagonized by hypokalemia   Hypokalemia   with the above drugs   Furosemide  .

Suxamethonium

  • Large doses of lidocaine may prolong suxamethonium-induced apnea.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

Organisation(s)


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