Lapis ISSN 2398-2969

Halothane

Contributor(s): Molly Varga, Jill Pearson

Introduction

Name

  • Halothane.

Class of drug

  • Inhalational general anesthetic.

Description

Chemical name

  • 2-Bromo-2-chloro-1,1-trifluoroethane.

Molecular formula

  • C2HBrClF3.

Molecular weight

  • 197.38.

Physical properties

  • Volatile liquid.

Storage requirements

  • Protect from light.
  • May corrode certain metals.

Uses

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Indications

  • Halothane is an inhalational anesthetic   Anesthesia: overview  .
  • Potent and highly volatile so should be delivered only through a calibrated vaporizer.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Epinephrine and thiobarbiturates
  • Increased risk of arrhythmia.

Opioid agonists, benzodiazepines, and nitrous oxide

  • Reduce concentration of halothane required to achieve surgical anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedandVetMedResource.
  • Gonzalez A, Silvan G, Garcia-Partida P & Illera J C (2006)Serum glucocorticoid concentrations after halothane and isoflurane anesthesia in New Zealand white rabbits.Vet Rec159(2), 51-51PubMed.
  • Gonzalez Aet al(2005)Serum catecholamine levels after halothane and isoflurane anaesthesia in rabbits.Vet Rec157(19), 589-590PubMed.
  • Imai A, Steffey E P, Ilkiw J E & Farver T B (1999)Comparison of clinical signs and hemodynamic varaibles used to monitor rabbits during halothane- and isoflurane-induced anesthesia.Am J Vet Res60(10), 1189-1195PubMed.
  • Flecknell P A & Liles J H (1996)Halothane anaesthesia in the rabbit - a comparison of the effects of medetomidine, acepromazine and midazolam on breath-holding during induction.J Ass Vet Anaesth23(1), 11-14VetMedResource.
  • Drummond J C (1985)MAC for halothane, enflurane, and isoflurane in the New Zealand White rabbit and a test for the validity of MAC determinations.Anesthesiology62, 336-338PubMed.

Other sources of information

Organisation(s)


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