Lapis ISSN 2398-2969

Glycopyrronium

Synonym(s): Glycopyrrolate bromide

Contributor(s): Anna Meredith, John Chitty

Introduction

Name

  • Glycopyrronium bromide.

Class of drug

  • Antimuscarinic agent.

Description

Chemical name

  • 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide.

Molecular formula

  • C19H28BrNO3.

Molecular weight

  • 398.33.

Uses

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Indications

  • Used pre-operatively to decrease oral and bronchial secretions and block vagal inhibitory reflexes.
  • In conjunction with long-acting anticholinesterase drugs, eg neostigmine, pyridostigmine during antagonism of neuromuscular block.
  • Pupil dilation in uveitis.

Administration

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Precautions

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Interactions

with other drugs

Atropine, chlorpromazine, 5% dextrose, diphenhydramine, droperidol/fentanyl, lidocaine, morphine, neostigmine, pethidine, promazine, pyridostigmine, Ringer's solution and 0.9% sodium chloride
  • Glycopyrronium is physically compatible.

Alkaline drugs, eg barbiturates

  • When mixed a precipitate may form.

Antihistamines, benzodiazepines, prolonged corticosteroid use (may increase intraocular pressure), pethidine, phenothiazines, procainamide and quinidine

  • The adverse effects of antimuscarinics may be increased.

Nitrofurantoin, sympathomimetics and thiazide diuretics

  • Antimuscarinics may enhance the action.

Metoclopramide

  • Antimuscarinics may antagonize metoclopramide   Metoclopramide  .

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Derived from The Veterinary Formulary. 4th edn (1998) Bishop Y (Ed). British Veterinary Association and Royal Pharmaceutical Society.

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