Lapis ISSN 2398-2969

Fusidic acid

Contributor(s): Ron Rees Davies

Introduction

Name

  • Fusidic acid.

Class of drug

  • Narrow spectrum fusidane antibiotic.

Description

Chemical name

  • (17Z)-16beta-acetoxy-3alpha, 11alpha-dihydroxyfusida-17(20), 24-dien-21-oic acid.

Molecular weight

  • 517 in the anhydrous form.

Physical properties

  • Poorly soluble in water, therefore prepared as the diethanolamine or sodium salts in some preparations.

Uses

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Indications

  • For treatment of fusidic acid-sensitive bacterial infections.
  • Predominitely effective against gram-positive bacteria.
  • Has very good activity against staphylococci, includingStaphylococcus intermediusand most strains ofStaphylococcus aureus, including beta-lactamase-producing and methicillin-resistant strains, corynebacteriae, clostridae, and Actinomyces spp.
  • The genera Streptococcus,Neisseria (Branhamella),Bacillus,Bordetella  Bordetella bronchiseptica  andMycobacteriaare moderately sensitive.
  • Most coliform bacteria and fungi are resistant.
  • Used in treatment of bacterial blepharitis, conjunctivitis, and dacryocystitis associated withStaphylococcus aureusandS. intermedius.
  • Skin infections caused by gram-positive bacteria particularly surface pyodermas.
  • Treatment of otitis externa.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers


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