ISSN 2398-2969      

Furosemide

Clapis

Synonym(s): Frusemide


Introduction

Name

  • Furosemide.

Class of drug

  • Loop diuretic.

Uses

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Indications

  • Used in the management of:
    • Congestive cardiac failure.
    • Pulmonary edema.
    • Non-cardiogenic ascites.
    • Hypercalcuric nephropathy.
    • Acute renal failure   Kidney: renal failure  .
    • Hyperkalemia.
    • Hypertension.
    • Urolithiasis   Urolithiasis  .

Congestive heart failure

  • There is evidence, although yet to be proven, that frusemide may acutely increase venous capacitance. This would be of benefit in the management of congestive cardiac failure.

The use of chronic diuretic monotherapy in the management of cardiac failure should be avoided, as patients receiving diuretics alone may deteriorate more rapidly than those receiving ACE inhibitors or digoxin concurrently.

Administration

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Precautions

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Interactions

with other drugs

ACE inhibitors and digoxin
  • Combination of furosemide, ACE inhibitor and digoxin with a sodium restricted diet may be associated with mild hyperkalemia   Hyperkalemia  .

Theophylline

  • May be enhanced when given with furosemide.

Aminoglycosides

  • Nephrotoxicity associated with the aminoglycosides may be potentiated.

Digoxin

  • Furosemide may induce hypokalemia   Hypokalemia  , thereby increasing the risk of digoxin toxicity.

Tubocurarine

  • May inhibit the muscle relaxation qualities.

Suxamethonium

  • Effects of suxamethonium may be increased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.
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