Lapis ISSN 2398-2969

Enrofloxacin

Contributor(s): Jill Pearson

Introduction

Name

  • Enrofloxacin.

Class of drug

  • Fluoroquinolone antibiotic.

Uses

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Indications

  • Pasteurellosis.
  • Gram-negative infections:Pseudomonasspp   Pseudomonads  ,Klebsiellaspp,Escherichia coli  Escherichia coli  ,Proteusspp   Proteus spp  andSalmonellaspp   Salmonella spp  .
  • Other infections:Staphylococcusspp   Staphylococcus spp  ,Pasturellaspp   Pasteurella multocida  andMycobacteriaspp.
  • Enrofloxacin is effective against many beta-lactamase producing bacteria.
  • The fluoroquinolones are highly lipophilic drugs which attain high concentrations within the cells of many tissues and are particularly effective in the management of soft tissue, urogenital (including prostatic) and skin infections.
    Not effective against anaerobic infections

Administration

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Precautions

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Interactions

with other drugs

Adsorbents and antacids containing cations (Mg, Al)
  • May bind to enrofloxacin and prevent its absorption.

Sucralfate and zinc salts

Probenecid/Cisapride

  • Blocks the tubular secretion of enrofloxacin and may increase its blood level and half-life.

NSAIDs

  • In man concurrent use of enrofloxacin and NSAIDs potentiates adverse CNS effects in epileptic patients.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bregante M A, Saez P, Aramayona J J et al (1999) Comparative pharmacokinetics of enrofloxacin in mice, rats, rabbits, sheep, and cows. Am J Vet Res 60 (9), 1111-1116 PubMed.

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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