Lapis ISSN 2398-2969

Doxapram

Synonym(s): Dopram-V

Contributor(s): Anna Meredith

Introduction

Name

  • Doxapram.

Class of drug

  • Central nervous system (CNS)/respiratory stimulant.

Uses

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Indications

  • Doxapram may be used to stimulate respiration in certain types of peri-operative respiratory depression, and in neonates.
  • Doxapram is preferred to naloxone when respiration is depressed by high doses of opioids, in animals which have undergone major surgery, as it does not affect opioid induced analgesia. However in these circumstances doxapram activity is short-lived and may be followed by profound respiratory depression unless repeated doses or an infusion is given. Alternatively, an opioid antagonist may be given.
  • Doxapram may be given to differentiate central (anesthetic overdose) from peripheral (neuromuscular blockade) causes of respiratory depression in animals given non-depolarizing muscle relaxants.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Hypertension may occur with sympathomimetics.
  • The use of theophylline concurrently with doxapram may cause increased CNS stimulation.
  • As doxapram may stimulate the release of epinephrine   Epinephrine  , its use within 10 minutes of the administration of anesthetic agents that sensitize the myocardium to catecholamines, eg halothane   Halothane  , enflurane, should be avoided.
  • Doxapram may mask the effects of muscle-relaxant drugs.
  • Doxapram is compatible with 5% dextrose or normal saline, but is incompatible with aminophylline, sodium bicarbonate   Sodium bicarbonate  and thiopentone   Thiopental  .

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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