Lapis ISSN 2398-2969

Digoxin

Synonym(s): Lanoxin

Contributor(s): Lesa Thompson, Sarah Pellett

Introduction

Name

  • Digoxin.

Class of drug

  • Cardiac glycoside.

Description

Chemical name

  • (3beta,5beta,12beta)-3-{[2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide.

Molecular formula

  • C41H64O14.

Molecular weight

  • 780.94.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can be administered in combination with Angiotensin-converting enzyme (ACE) inhibitors.
  • Antacids and metoclopramide   Metoclopramide  can reduce digoxin absorption from the gastrointestinal tract.
  • Diazepam   Diazepam  , loop and thiazide diuretics, tetracycline   Tetracycline  and verapamil   Verapamil  can increase serum digoxin levels, decrease elimination rate or enhance toxic side effects.  Decrease dose and monitor digoxin serum levels and adjust accordingly.
  • Spironolactone may enhance or decrease the toxic effects of digoxin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Amin E N, Abdel-Alim A A, Abdel-Moty S G et al (2010) Synthesis of new 4,5-3(2H)pyridazinone derivatives and their cardiotonic, hypotensive and platelet aggregation inhibition activities. Arch Pharm Res 33 (1), 25-46 PubMed.
  • Reusch B (2005) Investigation and management of cardiovascular disease in rabbits. In Practice 27 (8), 418-425 VetMedResource.

Other sources of information

  • Orcutt C (2014) Cardiovascular Disease. In:BSAVA Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA, Gloucester.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Raftery A (2013) Cardiovascular Disease. In:Clinical Veterinary Advisor.  Birds and Exotics Pets.Eds: Mayer J & Donnelly T M.  Elsevier, Missouri.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website:www.gov.uk/government/collections/veterinary-medicines-guidance-notes-vmgns.
  • Oglesbee B (2011) Congestive Heart Failure. In:Blackwells Five-Minute Veterinary Consult: Small Mammal. Wiley Blackwell, Iowa.

Organisation(s)


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