Lapis ISSN 2398-2969

Diazepam

Contributor(s): Jill Pearson

Introduction

Name

  • Diazepam.

Class of drug

  • Benzodiazepine.

Uses

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Indications

  • Premedicant.
  • Anticonvulsant.
  • Anxiolytic.
  • Muscle relaxant, urethral muscle spasm.
  • Anesthesia.
  • May be used with ketamine   Ketamine  or fentanyl   Fentanyl  to offset the muscle hypertonicity associated with dissociative anesthesia.
  • Used in combination with acepromazine and/or opioids for pre-anesthetic medication in the critically ill patient.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Cimetidine, erythromycin, and omeprazole
  • These drugs inhibit the metabolism of diazepam and may cause increased plasma concentrations.

Beta-1 antagonists

  • Duration of action of diazepam may be prolonged.
  • Hypotension may be enhanced if diazepam is used in conjunction with propranolol.

Antihistamines or opioid analgesics

  • Sedative effect may be enhanced.

Digoxin

  • The effects of digoxin may be increased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Ghaffari M S, Moghaddassi A P & Bokaie S (2009) Effects of intramuscular acepromazine and diazepam on tear production in rabbits. Vet Rec 164 (5), 147-148 PubMed.

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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