Lapis ISSN 2398-2969

Buprenorphine

Contributor(s): Molly Varga, Jill Pearson

Introduction

Name

  • Buprenorphine.

Class of drug

  • Long-acting partial opioid antagonist-agonist.

Description

Chemical name

  • (2-5R,6R,7R,14S)-9alpha-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol.

Molecular formula

  • C29H41NO4.

Molecular weight

  • 467.64.

Storage requirements

  • Protect from light.

Uses

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Indications

  • May be mixed with acepromazine   Acepromazine maleate  to produce neuroleptanalgesia for minor procedures or pre-operative medication.
  • Used to relieve moderate pain.
  • Sedative and euphoric effects less marked than those produced by morphine.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Opioid analgesics
  • Do not use in conjunction with these as it is a partial agonist and will antagonize the effects of full agonists (morphine   Morphine  , pethidine   Pethidine  ).
  • May potentiate sedative and ventilatory depressant effects of other CNS depressants.
  • Can be used to reverse sedative effects of fentanyl/fluanisone   Fentanyl  while maintaining analgesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

Organisation(s)


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