Lapis ISSN 2398-2969

Alfaxalone/alfadalone

Synonym(s): Alfaxolone/alfadolone, Alphaxalone/alphadalone, Alphaxolone/alphaxolone

Contributor(s): Jill Pearson, Lesa Thompson, Molly Varga

Introduction

Name

  • Alfaxalone/alfadalone (INN).
  • Alphaxalone/alphadalone (BAN).

Class of drug

  • Steroid general anesthetic.

Description

Chemical name

  • (3alpha,5alpha)-3-Hydroxypregnane-11,20-dione.

Molecular formula

  • C21H32O3.

Molecular weight

  • 332.48.

Physical properties

  • Clear, slightly viscous solution.

Storage requirements

  • Store below 25°C/77°F.
  • Do not refrigerate (steroid constituents may precipitate).
  • Protect from light.
  • Do not store opened vials (no antibacterial agent included).

Uses

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Indications

  • General anesthesia in various small animals.
  • Low doses given IM produce sedation.

Administration

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Precautions

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Interactions

With other drugs

Premedicants, eg phenothiazine
  • Prolonged anesthesia and recovery time Acepromazine maleate.
  • Barbiturates must not be used in animals sedated with alphadalone/alphaxalone.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Navarrete-Calvo R, Gómez-Villamandos R J, Morgaz J et al (2014) Cardiorespiratory, anaesthetic and recovery effects of morphine combined with medetomidine and alfaxalone in rabbits. Vet Rec 174 (4), 95 PubMed.
  • Green C J, Hasley M J, Precious S et al (1978) Alphaxolone-alphadolone anaesthesia in laboratory animals. Lab Anim 12 (2), 85-89 PubMed.

Other sources of information

Organisation(s)


ADDED