Lapis ISSN 2398-2969

Alfaxalone

Synonym(s): Alfaxolone, Alphaxalone, Alphaxolone, Alfaxan

Contributor(s): Vetstream Ltd, Vicki Baldrey

Introduction

Name

  • Alfaxalone (INN).
  • Alphaxalone (BAN).

Class of drug

  • Steroid general anesthetic.

Description

Chemical name

  • 3-hydroxy-5-pregnane-11, 20-dione.

Physical properties

  • Clear, colorless solution for injection presented in a multi dose bottle.
  • pH of solution: 6.5-7.0.
  • Concentration: 10 mg/ml.

Storage requirements

  • Store below 30°C/86°F.
  • Protect from light.
  • Solution contains no preservatives.
  • Recommended that contents of vial be used within 24 h of opening.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Huynh M, Poumeyrol S, Pignon C et al (2015) Intramuscular administration of alfaxalone for sedation in rabbits. Vet Rec 176 (10), 255 PubMed.
  • Marsh M K, Mcleod S R, Hansen A et al (2009) Induction of anaesthesia in wild rabbits using a new alfaxalone formulation. Vet Rec 164 (4), 122-123 PubMed.
  • Grint N J, Smith H E & Senior J M (2008) Clinical evaluation of alfaxalone in cyclodextrin for the induction of anaesthesia in rabbits. Vet Rec 163 (13), 395-396 PubMed.

Other sources of information

  • Meredith A (2015) Small Animal Formulary, Part B: Exotics.  9th edn. BSAVA, Quedgeley, Gloucester, UK.
  • Jurox Pty Ltd (2011) Alfaxan® Anaesthetic Injection Technical Notes. Rutherford, NSW, Australia. Website: www.jurox.com/downloads/product-material/Alfaxan_3.pdf. Last Accessed 23 November 2016.

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