Lapis ISSN 2398-2969

Acepromazine maleate

Synonym(s): ACP

Contributor(s): Molly Varga, Jill Pearson

Introduction

Name

  • Acepromazine maleate.

Class of drug

  • Phenothiazine.

Description

Chemical name

  • 1-{10-[3-(Dimethylamino)propyl]-12H-phenothiazin-2yl}ethanone.

Molecular formula

  • C19H22N2OS.

Molecular weight

  • 326.46.

Physical properties

  • Yellow crystalline solid or powder.

Storage requirements

  • Protect from light.

Uses

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Indications

  • Sedation Sedation.
  • Premedication Anesthesia: preparation - provides moderate tranquilization but no analgesia.
  • Sedation for GIT contrast studies as minimal effect on transit time.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Other central nervous system (CNS) depressant agents (barbiturates, narcotics, anesthetics) may cause additive CNS depression if used with acepromazine.
  • Quinidine when given with phenothiazines may cause additive cardiac depression.
  • Antidiarrheal mixtures, eg kaolin/pectin, bismuth subsalicylate, and antacids may cause reduced gastrointestinal (GI) absorption of oral phenothiazines.
  • Increased blood levels of both drugs may result if propranolol is administered with phenothiazines.
  • As phenothiazines block alpha-adrenergic receptors, concomitant use with epinephrine Epinephrine may lead to unopposed beta activity, thereby causing vasodilation and tachycardia.
  • Phenytoin metabolism may be decreased if given concurrently with phenothiazines.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ghaffari M S, Moghaddassi A P & Bokaie S (2009) Effects of intramuscular acepromazine and diazepam on tear production in rabbits. Vet Rec 164 (5), 147-148 PubMed.
  • Flecknell P A & Liles J H (1996) Halothane anaesthesia in the rabbit - a comparison of the effects of medetomidine, acepromazine and midazolam on breath-holding during induction. J Ass Vet Anaesth 23 (1), 11-14 VetMedResource.

Other sources of information

Organisation(s)


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