Lapis ISSN 2398-2969

Tyzzer's Disease

Introduction

  • CauseClostridium piliforme.
  • Signs: diarrhea, dehydration, death.
  • Diagnosis: histological examination, post-mortem of affected organs, visualization of clostridia, ELISA available.
  • Treatment: aggressive fluid therapy, antibiosis, provision of a high fiber diet.
  • Prognosis: poor in young rabbits, however older rabbits may survive.

Disease presentation

  • The disease is endemic in many rabbit colonies.
  • Young weanling rabbits present with diarrhea, depression, death.
  • Clinical disease is seen especially at times of stress or under poor hygienic conditions.
  • In older rabbits a chronic form may present.

Etiology

  • Caused by Clostridium piliforme  Clostridium piliforme  , a gram-negative, obligate intracellular spore-forming rod bacterium.
  • Stress or over-crowding often implicated.

Transmission

  • Via the feco-oral route, usually contaminated feed or bedding.

Other species affected

  • Hamsters, gerbils, rats, mice.

Diagnosis

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Differential diagnosis

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Treatment

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Prognosis

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Further Reading

Publications

Refereed papers
  • Recent references fromPubMed.
  • Lord B (2012)Gastrointestinal disease in rabbits 2. Intestinal diseases. In Pract34(3), 156-162.
  • Franklin C L, Motzel S L, Besch-Williford C L, Hook R Jr, Riley L K (1994)Tyzzer's infection -host specificity of Clostridium piliformeisolates. Lab Anim SciDec44(6), 568-572PubMed.
  • Lee W K, Fujisawa T, Kawamura S, Itoh K, Mitsuoka T (1991)Isolation and identification of clostridia from the intestine of laboratory animals. Lab AnimJan25(1), 9-15PubMed.
  • Carman R J & Evans R H (1984)Experimental and spontaneous clostridial enteropathies of laboratory and free living lagomorphs. Lab Anim SciOct34(5), 443-452PubMed.
  • Goto K & Itoh T (1996)Detection of Clostridium piliformeby enzymatic assay of amplified cDNA segment in microtitration plates. Lab Anim SciOct46(5), 493-496PubMed.

Other sources of information

  • Meredith A & Crossley D A (2002)Rabbits.In: Manual of Exotic Pets.BSAVA. Glos, UK. pp 76-92.
  • Deeb B (2000)Digestive System and Disorders.In: Manual of Rabbit Medicine and Surgery.BSAVA. Glos, UK. pp 39-46.


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