Lapis ISSN 2398-2969

Tyzzer's Disease

Introduction

  • CauseClostridium piliforme.
  • Signs: diarrhea, dehydration, death.
  • Diagnosis: histological examination, post-mortem of affected organs, visualization of clostridia, ELISA available.
  • Treatment: aggressive fluid therapy, antibiosis, provision of a high fiber diet.
  • Prognosis: poor in young rabbits, however older rabbits may survive.

Disease presentation

  • The disease is endemic in many rabbit colonies.
  • Young weanling rabbits present with diarrhea, depression, death.
  • Clinical disease is seen especially at times of stress or under poor hygienic conditions.
  • In older rabbits a chronic form may present.

Etiology

  • Caused by Clostridium piliforme  Clostridium piliforme  , a gram-negative, obligate intracellular spore-forming rod bacterium.
  • Stress or over-crowding often implicated.

Transmission

  • Via the feco-oral route, usually contaminated feed or bedding.

Other species affected

  • Hamsters, gerbils, rats, mice.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Differential diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Prognosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lord B (2012) Gastrointestinal disease in rabbits 2. Intestinal diseases. In Pract 34 (3), 156-162 VetMedResource.
  • Goto K & Itoh T (1996) Detection of Clostridium piliforme by enzymatic assay of amplified cDNA segment in microtitration plates. Lab Anim Sci Oct 46 (5), 493-496 PubMed.
  • Franklin C L, Motzel S L, Besch-Williford C L et al (1994) Tyzzer's infection -host specificity of Clostridium piliforme isolates. Lab Anim Sci 44 (6), 568-572 PubMed.
  • Lee W K, Fujisawa T, Kawamura S et al (1991) Isolation and identification of clostridia from the intestine of laboratory animals. Lab Anim 25 (1), 9-15 PubMed.
  • Carman R J & Evans R H (1984) Experimental and spontaneous clostridial enteropathies of laboratory and free living lagomorphs. Lab Anim Sci Oct 34 (5), 443-452 PubMed.

Other sources of information

  • Meredith A & Crossley D A (2002) Rabbits. In: Manual of Exotic Pets. BSAVA. Glos, UK. pp 76-92.
  • Deeb B (2000) Digestive System and Disorders. In: Manual of Rabbit Medicine and Surgery. BSAVA. Glos, UK. pp 39-46.


ADDED