Lapis ISSN 2398-2969

Therapeutics: glucocorticoids

Synonym(s): Steroids, Steroidal anti-inflammatories, Corticosteroids, Glucocorticoids

Contributor(s): Sarah Pellett, Vicki Baldrey

Introduction

  • Used in human and veterinary medicine for their anti-inflammatory, immunosuppressive and anti-fibrotic effects.

Corticosteroid use can be detrimental in rabbits.

  • Severe pathological changes can occur even with small, one off doses.
  • Development of hepatic lipidosis   Liver: hepatic lipidosis   can occur as a consequence of corticosteroid administration due to the mobilization of free fatty acids from adipose tissue.
  • Corticosteroid use can induce immunosuppression in rabbits; steroid administration in rabbits can cause lysis of white blood cells. This can cause activation of latent infections such as encephalitozoonosis   Encephalitozoonosis  , C. piliforme  Clostridium piliforme  or pasteurellosis   Pasteurellosis  .
  • Other adverse effects include delayed wound healing, gastric ulceration and the onset of iatrogenic diabetes mellitus.
  • Careful consideration of use and monitoring should ensue if corticosteroids must be used, eg as part of a chemotherapy protocol, or for immune modulating effects, although immune-mediated disease in rabbits is extremely rare.

Routes of administration

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Uses

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Examples of available agents

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Precaution

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Further Reading

Publications

Refereed papers

Other sources of information

  • Varga M (2014) Textbook of Rabbit Medicine. 2nd edn. Butterworth Heinemann Elsevier, Edinburgh. 
  • Robat C & Mayer J (2013) Lymphosarcoma. In: Clinical Veterinary Advisor. Birds and Exotics Pets. Eds: Mayer J & Donnelly T M. Elsevier, Missouri.
  • Oglesbee B (2011) Anterior Uveitis. In: Blackwells Five-Minute Veterinary Consult: Small Mammal. Wiley Blackwell, Iowa.
  • Pollock C (2006) Therapeutics. In: BSAVA Manual of Rabbit Medicine and Surgery. 2nd edn. Eds: Meredith A & Flecknell P. BSAVA, Gloucester.


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