ISSN 2398-2969      

Nutrition: muscular dystrophy

Clapis
Contributor(s):

Molly Varga

Anna Meredith

Synonym(s): Muscular dystrophy, Nutritional myopathy


Introduction

  • Muscular dystrophy is the principal clinical sign of hypovitaminosis E Hypovitaminosis E.
  • Cause: deficiency of vitamin E.
  • Signs: hindlimb weakness Floppy rabbit syndrome that progresses to hindlimb paralysis Paresis / paralysis: limb is seen in weanling rabbits (3-10 weeks of age).
  • In many species, deficiency of vitamin E and or selenium can result in nutritional muscular dystrophy which resolves with the supplementation of either nutrient - this is not the case in rabbits, selenium supplementation has no effect. This is thought to be because of the relatively abundant non-selenium glutathione peroxidases present in the rabbit.
  • Diagnosis: serology, fecal evaluation, hematology, electrolyte levels, radiography.
  • Treatment: pain relief; address concomitant issues, eg urine scalding, hepatic coccidiosis; ensure fluid/nutritional requirements are met; vitamin E supplementation; supportive care.
  • Prognosis: poor if severe.
Print off the Owner factsheet on Muscular dystrophy and other muscular conditions to give to your clients.

Presenting signs

Acute presentation

Age predisposition

  • Typically reported in juvenile rabbits 3-10 weeks of age.

Cost considerations

  • May be significant in breeding colonies.

Special risks, eg anesthetic

  • May be potential for concurrent myocardial dysfunction in hypovitaminosis E which poses an increased anesthetic risk.

Pathogenesis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Castellini C, Mourvaki E, Dal Bosco A et al (2007) Vitamin E - biology and function: A case study in male rabbit. Reprod Dom Anim 42 (3), 248-256 PubMed
  • Czarnecki W & Zimmer L (2006) Pharmacokinetics and bioavailability of alpha-tocopherol in rabbits. Annales Universitatis Mariae Curie-Skladowska Lublin-Polonia 19 (2, 22), 153-160.
  • Schneider C (2005) Chemistry and biology of vitamin E. Mol Nutr Food Res 49 (1), 7-30 PubMed.
  • St Claire M B, Kennett M J & Besch-Williford C L (2004) Vitamin A toxicity and vitamin E deficiency in a rabbit colony. Contemp Top Lab Anim Sci 43 (4), 26-30 PubMed
  • Axford-Gatley R A & Wilson G J (1990) Reduction of experimental myocardial infarct size by oral administration of alpha-tocopherol. Cardiovasc Res 25 (2), 89-92 PubMed.
  • Godfried S L, Combs G F Jr., Saroka J M et al (1989) Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E. Br J Nutr 61 (3), 607-617 PubMed.
  • Bardosi A & Dickmann U (1987) Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E. Acta Neuropathologica 75 (2), 166-172 PubMed.
  • Yang N Y J & Desai I D (1977) Effect of high levels of dietary vitamin E on hematological indices and biochemical parameters in rats. J Nutr 107 (8), 1410-1417 PubMed.
  • March B E, Wong E, Seier L et al (1972) Hypervitaminosis E in the chick. J Nutr 103 (3), 371-377 PubMed.

Other sources of information

  • Higdon J, Drake V J & Traber M G (2008) Vitamin E. Oregon State University, Linus Pauling Institute, Micronutrient Information Center. Website:http://lpi.oregonstate.edu/infocenter/vitamins/vitaminE.
  • Higdon J, Drake V J & Russell R M (2007) Vitamin A. Oregon State University, Linus Pauling Institute, Micronutrient Information Center. Website:http://lpi.oregonstate.edu/infocenter/vitamins/vitaminA.
  • Harcourt-Brown F (2002) Textbook of Rabbit Medicine. Butterworth Heinemann.
  • McDonald P, Edwards R A, Greenhalgh J F D & Morgan C A (1996) Animal Nutrition. 5th edn. Longman.
  • Lowe J A (1998) Pet Rabbit Feeding and Nutrition. In: Nutrition of the Rabbit.Eds: de Blas C & Wiseman J. CABI Publishing. pp 309-332.
  • Cheeke P R (1994) Nutrition and Nutritional diseases. In: Biology of the Laboratory Rabbit.2nd edn. Eds: Manning P J, Ringler D H & Newcomer C E. Academic Press. pp 321-333.
  • Hunt C E & Harrington D D (1974) Nutrition and Nutritional diseases of the Rabbit. In: Biology of the Laboratory Rabbit. 1st edn. Eds: Manning P J, Ringler D H & Newcomer C E. Academic Press. pp 403-428.

Organizations

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code