Lapis ISSN 2398-2969

Hypervitaminosis E

Synonym(s): Vitamin E toxicity

Contributor(s): Molly Varga, Anna Meredith

Introduction

  • Vitamin E   Vitamin E  exhibits very low toxicity and therefore hypervitaminosis E is extremely rare.
  • Cause: it could theoretically occur in rabbits fed on an incorrectly formulated diet   Nutrition: dietary requirements  .
  • Signs: it has not yet been reported in the veterinary literature.
  • Diagnosis: dietary analysis, hematology, blood biochemistry.
  • Treatment: none as rare.
  • Prognosis: depends on severity.

Presenting signs

  • Not reported in rabbits.
  • Signs in humans include diarrhea, flatulence and bloating; this progresses to lethargy and weakness.

Acute presentation

  • No rabbit specific information recorded.
  • Reduced growth rate reported in chicks, with reduced skeletal calcification, increased requirement for vitamin D, reduced PCV and increased prothrombin time.

Cost considerations

  • Possibly significant in a breeding colony situation.

Pathogenesis

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Diagnosis

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Treatment

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Prevention

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Sequelae

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Castellini C, Mourvaki E, Dal Bosco A et al (2007) Vitamin E biochemistry and function: A case study in male rabbit. Reprod Dom Anim 42 (3), 248-256 PubMed.
  • Czarnecki W & Zimmer L (2006) Pharmacokinetics and bioavailability of alpha-tocopherol in rabbits. Annales Universitatis Mariae Curie-Skladowska Lublin-Polonia 19 (2, 22), 153-160.
  • Schneider C (2005) Chemistry and biology of vitamin E. Mol Nutr Food Res 49 (1), 7-30 PubMed.
  • Axford-Gatley R A & Wilson G J (1990) Reduction of experimental myocardial infarct size by oral administration of alpha-tocopherol. Cardiovasc Res 25 (2), 89-92 PubMed.
  • Godfried S L, Combs G F Jr., Saroka J M et al (1989) Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E. Br J Nutr 61 (3), 607-617 PubMed.
  • Bardosi A & Dickmann U (1987) Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E. Acta Neuropathol 75 (2), 166-172 PubMed.
  • Jack Yang N Y & Desai I D (1976) Effect of high levels of dietary vitamin E on hematological indices and biochemical parameters in rats. J Nutr 107 (8), 1410-1417 PubMed.


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