Lapis ISSN 2398-2969

Papilloma virus

Synonym(s): Warts

Contributor(s): Vetstream Ltd, Susan Dawson, Molly Varga

Introduction

Classification

Taxonomy

  • Papovaviridaefamily.

Active Forms

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Clinical Effects

Epidemiology

Lifecycle

  • Little is definitively known.
  • The virus is found in the oral cavity of rabbits without lesions.
  • Entrance into keratinocytes through traumatic lesions allows viral replication.

Transmission

  • Experimental infection by scarification of the skin.
  • Natural transmission is by direct contact: infective particles shed from oral lesions contact the oral mucosa of the naive animal. The mucosal integrity must be compromised in order for the virus to enter.

Pathological effects

  • Age-resistance in most animals. Lesions spontaneously regress.
  • Benign warts.

Other Host Effects

  • Species specific.
  • Possible progression to malignancy (although not confirmed).

Control

Control via animal

  • Isolation of infected animals would prevent spread, however this is not generally necessary.

Vaccination

  • Autogenous vaccines available but of dubious efficacy.

Diagnosis

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Further Reading

Publications

Refereed papers

Other sources of information

  • DiGiacomo R F & Mare C J (1994 )Viral diseases.In:The Biology of the Laboratory Rabbit.Eds: Manning P J, Ringler D H & Newcomer C E. 2nd edn. San Diego, Academic Press. pp 171-204.

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