ISSN 2398-2950      

Scintigraphy: renal for GFR

ffelis
Contributor(s):

Fraser J McConnell


Introduction

  • Use of radionucleotide which is excreted through kidneys allows some assessment of renal function and structure.
  • Used commonly in human medicine.

Uses

  • Assessing renal function:
    • Measurement of glomerular filtration rate (GFR).
    • Measurement of effective renal plasma flow (ERPF).

Advantages

  • Measurement of GFR allows earlier detection of renal dysfunction Renal function assessment than elevation of BUN or creatinine:
    • Prior to nephrectomy Ureteronephrectomy.
    • Allows monitoring of patient and assessment of treatment response.
    • Allows dose adjustment prior to treatment with nephrotoxic agents, eg cisplatin Cisplatin.

Disadvantages

  • Cost.
  • Limited availability.
  • Radiation hazard (minimal).
  • Requires patient to be isolated for a period after injection of radionucleotide.

Requirements

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Preparation

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Procedure

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Aftercare

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Peters A M (1998) Scintigraphic imaging of renal function. Exp Nephrol (5), 391-397 PubMed.
  • Itkin R J, Krawiec D R, Twardock A R et al (1994) Quantitative renal scintigraphic determination of effective renal plasma flow in dogs with normal and abnormal renal function using 99mTc-mercaptoacetyltriglycine​. Am J Vet Res 55 (12), 1660-1665 PubMed.
  • Uribe D, Krawiec D R, Twardock A R et al (1992) Quantitative renal scintigraphic determination of the glomerular filtration rate in cats with normal and abnormal kidney function, using 99mTc-diethylenetriaminepentaacetic acid. Am J Vet Res 53 (7), 1101-1107 PubMed.

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