Felis ISSN 2398-2950

Pregnancy termination

Synonym(s): Mismate, abortion, mesalliance

Contributor(s): Bruce Eilts, Carlos Pinto, Autumn P Davidson

Introduction

  • Valuable queens, if misbred, can undergo medical abortion without negative impact on future reproductive potential.
  • Unwanted pregnancies contribute to the cat overpopulation problem.

Uses

Pharmacological intervention

  • Goal: since luteal function is need to support pregnancy in cats, one alternative is to use drugs that will negate luteal synthesis/secretion of progesterone:
    • Administration of PGF2 alpha (0.5-2 mg per cat) administered SC for 2-5 days will result in complete abortion. The efficacy is increased when pregnancy termination commences later in gestation (30-40 days after coitus).
  • Because prolactin promotes luteal support in queens, the administration of the synthetic antiprolactin drug, cabergolne Cabergoline, at an oral dose of 5-15 ug/kg/day for at least 5 days has been shown to induce abortions in all treated animals. Such later treatments, whilst more efficacious, are most likely to result in abortion of fetal material (in cases of very late abortion, the fetuses may be transiently alive necessitating euthanasia).
  • More recently, antiprogestins (progesterone receptor antagonist) have been shown to be a safe and efficacious alternative to elective termination of pregnancy in the queen. A reported protocol preconizes the administration of two injections 24 hours apart of aglepristone Aglepristone (RU 534) at a dose of 10/15 mg/kg (0.33/0.5 ml/kg) SC; then an ultrasound examination 7 and 14 days later to verify the need of a third injection in case there are remaining live fetuses.
  • Estrogens have been advocated in the past as a 'mismate' treatment but owing to their unknown efficacy and severity of potential side effects, their use is no longer advocated.

Advantages

  • Termination of pregnancy resulting from unwanted mating (misalliance) when ovariohysterectomy not acceptable.

Disadvantages

  • Side effects of drugs.
  • Abortion of fetuses may be esthetically unappealing to clients, making hospitalization or boarding of queens preferable during the treatment period.

Requirements

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Preparation

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Procedure

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Aftercare

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Outcomes

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Prognosis

  • Good for termination of pregnancy.
  • Good for future fertility.

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Goericke-Pesch S (2010) Reproduction control in cats: new developments in non-surgical methods. J Feline Med Surg 12 (7), 539-546 PubMed.

Other sources of information

  • Eilts B E (2002) Pregnancy termination in the bitch and queen. Clin Tech Small Anim Pract 17 (3), 116-123.


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