Felis ISSN 2398-2950

Urine cortisol : creatinine ratio

Contributor(s): David Bruyette

Overview

  • Elevated [blood cortisol]   →   elevated [corticosteroid metabolites] in urine.
  • Measurement of [corticosteroid metabolites] in 24-hour urine collections discriminates healthy animals from those with hyperadrenocorticism Hyperadrenocorticism.
  • Difficulty collecting 24-hour urine sample limits use of this technique.

Sampling

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Tests

Methodologies

  • Radioimmunoassay for cortisol.

Availability

  • Widely available.

Validity

Sensitivity

  • Highly sensitive in discriminating normal animals from those with hyperadrenocorticism.

Specificity

  • Poor specificity - many animals with concurrent disease eg diabetes Diabetes mellitus, have abnormal results.

Technique (intrinsic) limitations

  • Result affected by presence of blood in urine/urinary tract inflammatory disease.
  • Effects of blood.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Henry C J, Clark T P, Young D W and Spano J S (1996) Urine cortisol / creatinine ratio in healthy and sick cats. JVIM 10, 123-126.


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