Felis ISSN 2398-2950

PTH assay

Contributor(s): Penney Barber, David Bruyette

Overview

  • Parathyroid hormone (PTH) released from parathyroid glands.
  • Plasma calcium usually operates negative feedback system on PTH release.
  • Multiple metabolic fragments of PTH in circulation are cleared by glomerular filtration.
  • Only intact PTH molecule is active.

Sampling

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Tests

Methodologies

  • Immunoradiometric assay.
  • Modern assay is a sensitive 2-site intact PTH assay:
    • Measures functional parathyroid output.
    • More accurate assessment of hyperparathyroidism in renal failure (avoids measurement of retained inactive fragments).

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Barber P J, Elliot T J & Torrance A G (1993) Measurement of feline intact parathyroid hormone:assay validation and sample handling studies. JSAP 34, 614.
  • Barber P J, Torrance A G & Elliot T J (1994) Carboxyl fragment interference in assay of feline parathyroid hormone. JVIM 8, 168.


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