Felis ISSN 2398-2950

Pleural fluid: differential cell count

Contributor(s): Karen Gerber, Andy Torrance, Kim Willoughby, Prof Bernard Feldman

Overview

  • Normal pleural fluid is clear and colorless to slightly yellow, and is of low cellularity (<1000 nucleated cells/ml) and protein (<2.5 g/dl).
  • The number and type of cells found in pleural fluid varies with different conditions.
  • Inflammation increases cell count.
  • Cellularity generally increases in cases of modified transudates, eg heart disease Heart: congestive heart failure, neoplasia, and particularly inflammatory exudates Pleural effusion.

Sampling

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Tests

Methodologies

Availability

  • Widely available.
  • Can be performed in practice laboratory.

Technique (intrinsic) limitations

  • Clumping or fragmentation of cells may distort count.

Technician (extrinsic) limitations

  • Contamination of sample with blood may obscure the cell count.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Willard M D (1989) Fluid accumulation disorders. In: Small Animal Clinical Diagnosis by Laboratory Methods. 1st edn. Eds: M D Willard, Tvedton & Turnwald. Philadelphia: W B Saunders. pp 229-242.


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