Felis ISSN 2398-2950

Phenobarbital assay

Contributor(s): Rosanna Marsella

Overview

  • Most effective anticonvulsant in delaying progressive intensification of seizure activity.
  • Serum concentrations are not related to oral dose and depend on:
    • Gastrointestinal absorption (slowed by presence of food, diarrhea, and malabsorptive disorders).
    • Induction of drug-metabolizing hepatic enzymes.
    • Concurrent therapy.

Sampling

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Tests

Availability

  • Widely available.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Podell M (1998) Antiepileptic drug therapy. Clin Tech Small Anim Pract 13(3), 185-192.
  • Cochrane S M et al(1990) Pharmacokinetics of phenobarbital in the cat following multiple oral administration. Can J Vet Res 54(3), 309-312.
  • Cochrane S M et al(1990) Pharmacokinetics of phenobarbital in the cat following intravenous and oral administration. Can J Vet Res 54(1), 132-138.


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