Felis ISSN 2398-2950

NT-proBNP assay

Synonym(s): N-terminal proß-type natriuretic peptide assay

Contributor(s): Jordi Lopez-Alvarez, Keith Page, Vetstream Ltd


  • Cardiac biomarkers assist with the collection of evidence of cardiac disease.
  • NT-proBNP is now widely used to determine the presence of heart disease in cats, both by qualitative and quantitative methods.
  • It is not recommended to make decisions based on biomarker results in isolation of other clinical judgement and tests.


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  • One quantitative commercial assay (Cardiopet® proBNP Test, Idexx) and one qualitative assay (SNAP® Feline proBNP test) available worldwide. 

Result Data

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Further Reading


Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Oyama M A, Boswood A, Connolly D J, Ettinger S J, Fox P R, Gordon S G, Rush J E, Sisson D D, Stepien R L, Wess G, & Zannad F (2013) Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease. JAVMA 243(1), 71-82 PubMed.
  • Singletary G E, Rush J E, Fox P R, Stepien R L, & Oyama M A (2012) Effect of NT-pro-BNP assay on accuracy and confidence of general practitioners in diagnosing heart failure or respiratory disease in cats with respiratory signs. JVIM 26(3), 542-546 PubMed.
  • Fox P R, Rush J E, Teynolds C A, Defrancesco T C, Keene B W, Atkins C E, Gordon S G, Schober K E, Bonagura J D, Stepien R L, Kellihan H B, Macdonald K A, Lehmkuhl L B, Nguyenba T P, Sydney Moise N, Lefbom B K, Hogan D F, Oyama M A (2011) Multicenter evaluation of plasma N-terminal probrain natriuretic peptide (NT-proBNP) as a biochemical screening test for asymptomatic (occult) cardiomyopathy in cats. JVIM 25(5), 1010-1016 PubMed.
  • Wess G, Daisenberger P, Mahling M, Hischberger J, Hartmann K (2011) Utility of measuring plasma N-terminal pro-brain natriuretic peptide in detecting hypertrophic cardiomyopathy and differentiating grades of severity in cats. Vet Clin Pathol 40(2), 237-244 PubMed.
  • Connolly D J (2010)Natriuretic peptides: the feline experience. Vet Clin North Am Small Anim Pract 40(4), 559-570 PubMed.
  • Lalor S M, Connolly D J, Elliott J, Syme H M (2009) Plasma concentrations of natriuretic peptides in normal cats and normotensive and hypertensive cats with chronic kidney disease. J Vet Cardiol 11Suppl 1 S71-79 PubMed.