ISSN 2398-2950      

Blood biochemistry: vitamin B12

ffelis
Contributor(s):

Synonym(s): B12, cobalamin


Overview

  • Absorbed in association with intrinsic factor   →   decreased IF   →   decreased absorption of clot   →   low blood concentration.
  • Absorbed in ileum   →   malabsorption results in low levels in blood.
  • Utilized by small intestinal bacteria   →   GI obstruction   →   bacterial growth   →   bacterial overgrowth reduces levels.

Sampling

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Tests

Methodologies

  • Radioimmunoassay.
  • Chemiluminescent immunoassay.
  • Bioassays.

Availability

  • Specialist laboratory - must use assay that boils serum/plasma.
  • Canine and feline serum may contain binding proteins that need to be denatured and absorbed before measurement via a "charcoal boil" step. Human laboratories may not necessarily carry out this step, by preference use a laboratory that routinely measures vitamin B12 in veterinary species.

Technician (extrinsic) limitations

  • Specialized.

Result Data

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Reed N, Gunn-Moore D & Simpson K (2007) Cobalamin, folate and inorganic phosphate abnormalities in ill cats. J Fel Med Surg 9, 278-288 PubMed.
  • Simpson K W, Fyfe J, & Cornetta A et al (2001) Subnormal concentrations of serum cobalamin (Vitamin B12) in cats with gastrointestinal disease. JVIM 15, 26-32.

Other sources of information

  • Simpson J W (1998) Gastrointestinal system and exocrine pancreas. In: Manual of Small Animal Clinical Pathology. Eds: Davidson M, Else R & Lumsden J. BSAVA, UK.
  • Bush B M (1991) Interpretation of Laboratory Results. Blackwell Scientific Publication, UK.

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!