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Blood biochemistry: trypsin-like immunoreactivity

ffelis
Contributor(s):

Kathleen P Freeman

Synonym(s): Immunoreactive trypsin, IRT, TLI


Overview

  • Trypsin is a pancreatic proteolytic enzyme; if it leaks from pancreatic cells it causes pancreatitis Pancreatitis.
  • Immunoreactive trypsin (probably the trypsin precursor, trypsinogen) is present in serum/plasma and will react with anti-trypsin antibodies but has no proteolytic activity.
  • Decreased trypsin-like immunoreactivity (TLI) indicates exocrine pancreatic insufficiency Exocrine pancreatic insufficiency.
  • Increased TLI may be seen with pancreatitis.

Sampling

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Tests

Availability

  • GI Laboratory, Texas A&M University, USA.
  • SCL Bioscience Services, UK.
  • Many laboratories may have arrangements with the above specialist laboratories to perform this assay.

Validity

Sensitivity

  • Sensitive and specific for diagnosis of exocrine pancreatic insufficiency (EPI).
  • Sensitivity in pancreatitis are thought to be less than with EPI.
  • TLI may be elevated in cats with IBD. These cats may or may not have pancreatitis.

Specificity

  • Specificity in pancreatitis are thought to be less than with EPI.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Gerhardt A, Steiner J M, Williams D A, Kramer S, Fuchs C, Janthur M, Hewicker-Trautwein M & Nolte I (2001) Comparison of the sensitivity of different diagnostic tests for pancreatitis in cats. J Vet Intern Med 15 (4), 329-333.
  • Simpson K W, Fyfe J, Cornetta A, Sachs A, Strauss-Ayali D, Lamb S V & Reimers T J (2001) Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease. J Vet Intern Med 15 (1), 26-32.
  • Simpson K W (2000) The emergence of feline pancreatitis. J Vet Intern Med 15 (4), 327-328.
  • Swift N C, Marks S L, MacLachlan N J & Norris C R (2000) Evaluation of serum feline trypsin-like immunoreactivity for the diagnosis of pancreatitis in cats. JAVMA 217 (1), 37-42.
  • Bruner J M, Steiner J M, Williams D A, Van Alstine W G, Blevins W (1997) High feline trypsin-like immunoreactivity in a cat with pancreatitis and hepatic lipidosis. JAVMA 210 (12), 1757-1760.
  • Horney B (1996) Clinical pathology interpretation. Can Vet J 37 (4), 244-245.

Other sources of information

  • Ettinger S J & Feldman E C (2000) Eds. Textbook of Veterinary Internal Medicine.5th edn. W B Saunders & Co, USA. ISBN: 0 7216 6795 3.
  • Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals.5th edn. Academic Press, USA. ISBN: 0 1239 6305 2.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa University Press, USA.

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