Felis ISSN 2398-2950

Blood biochemistry: gamma glutamyl transferase

Synonym(s): gGT, Gamma glutamyl transpeptidase, GTP

Contributor(s): Kathleen P Freeman

Overview

  • Highest levels in renal tubular epithelial cells, canalicular surfaces of hepatocytes and bile duct epithelium. Also present in pancreas and small intestine.
  • Hepatobiliary system is main source of serum GGT in health and disease.
  • May be valuable in the cat where ALP has a short half-life.

Sampling

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Tests

Methodologies

  • Vary between laboratories.

Availability

  • Widely available.

Validity

Sensitivity

  • Lower sensitivity than ALP in detection of liver disease, but greater specificity.

Specificity

  • Lower specificity than ALP in detection of liver disease, but greater sensitivity.

Technique (intrinsic) limitations

  • Test results most significant in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Spano J A, August J R, Henderson R A, Dumas M B & Groth A H Jr (1983) Serum gamma-glutamyl transpeptidase activity in healthy cats and cats with induced hepatic disease. Am J Vet Res 44(11), 2049-2053.
  • Nilkumhang P & Thornton J R (1979) Plasma and tissue enzyme activities in the cat. JSAP 20(3), 169-174.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine.5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


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