ISSN 2398-2950      

Blood biochemistry: folate

ffelis

Overview

  • Water soluble vitamin absorbed in upper small intestine.
  • Dietary deficiency unlikely; [serum] reflect absorption in intestine.
  • Plentiful in most commercial pet foods.
  • Dietary levels can influence fasting serum levels, leading to an increase in fasting serum levels.

Sampling

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Tests

Methodologies

  • Radioimmunoassay.
  • Chemiluminescent immunoassay.
  • Bioassay.

Availability

  • Available at many commercial laboratories.

Validity

Sensitivity

  • Low sensitivity (estimated to be approximately 5%).

Specificity

  • High specificity.
  • Sensitivity and specificity are improved when combined interpretation with serum vitamin B12 determination.

Technique (intrinsic) limitations

  • Interpret in conjunction with other tests (especially vitamin B12/cobalamin and TLI), and in conjunction with clinical signs, presentation and history.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ettinger S J & Feldman E C (2000) Textbook of Veterinary Internal Medicine. 5th edn. Saunders and Co, USA.
  • Simpson J W (1998) Gastrointestinal system and exocrine pancreas. In: Manual of Small Animal Clinical Pathology. Eds: Davidson M, Else R & Lumsden J. BSAVA, UK.
  • Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
  • Bush B M (1991) Interpretation of Laboratory ResultsBlackwell Scientific Publications, UK.

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