ISSN 2398-2950      

Blood biochemistry: alkaline phosphatase

ffelis
Contributor(s):

Kathleen P Freeman

Synonym(s): ALP, Serum alkaline phosphatase, SAP


Overview

  • Number of isoenzymes produced in a range of tissues (liver, kidney, intestine, placenta).
  • Increased plasma levels are derived from liver and bone.
  • Good indicator of liver disease and cholestasis.
  • Short half-life of ALP in the cat, therefore any rise likely to be significant.

Sampling

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Tests

Methodologies

  • Method and normal range may vary between laboratories.
  • Electrophoretic or other separation method necessary to measure activity of individual isoenzymes.

Validity

Sensitivity

  • Sensitive indicator of cholestasis or hyperadrenocorticism Hyperadrenocorticism, but not specific.

Technique (intrinsic) limitations

  • Test results most significant when interpreted in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ettinger S J & Feldman E C (2000) Eds. Textbook of Veterinary Internal Medicine. 5th edn. W B Saunders & Co, USA.
  • Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa University Press, USA.

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