Felis ISSN 2398-2950

Blood biochemistry: alkaline phosphatase

Synonym(s): ALP, Serum alkaline phosphatase, SAP

Contributor(s): Kathleen P Freeman

Overview

  • Number of isoenzymes produced in a range of tissues (liver, kidney, intestine, placenta).
  • Increased plasma levels are derived from liver and bone.
  • Good indicator of liver disease and cholestasis.
  • Short half-life of ALP in the cat, therefore any rise likely to be significant.

Sampling

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Tests

Methodologies

  • Method and normal range may vary between laboratories.
  • Electrophoretic or other separation method necessary to measure activity of individual isoenzymes.

Validity

Sensitivity

  • Sensitive indicator of cholestasis or hyperadrenocorticism Hyperadrenocorticism, but not specific.

Technique (intrinsic) limitations

  • Test results most significant when interpreted in conjunction with other laboratory results and clinical findings.

Result Data

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


ADDED