Felis ISSN 2398-2950

Anti-diuretic hormone (ADH) test

Synonym(s): Desmopressin response test

Contributor(s): David Bruyette, Carmel Mooney

Overview

  • Performed at end of water deprivation test.
  • First demonstrate that animal is unable to concentrate urine on water deprivation Water deprivation test, then give synthetic antidiuretic hormone (ADH) Desmopressin.
  • In central diabetes insipidus (primary problem is lack of ADH production) nephrons should respond to exogenous ADH and urine concentration will occur.
  • In nephrogenic form of diabetes insipidus Diabetes insipidus, animal will be unable to respond to exogenous ADH and urine remains unconcentrated.
    Primary nephrogenic diabetes insipidus has not been reported in the cat.
  • Alternatively a controlled trial treatment with ADH may be given and clinical improvement gives an inferred diagnosis.

Sampling

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Tests

Availability

  • Easy to perform in practice with facilities to measure urine SG.
  • Osmolality measurements may not be available.

Technique (intrinsic) limitations

  • Bladder emptying requires catheterization (best to place indwelling catheter for duration of test).

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Borbst D (1989) Urinalysis and associated laboratory procedures. Vet Clin North Am Small Anim Pract 19(5), 929-949.


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