Felis ISSN 2398-2950

Vincristine

Contributor(s): William Brewer Jr, Laura Garrett

Introduction

Name

  • Vincristine sulfate.

Class of drug

  • Vinca alkaloid antineoplastic agent, derived from the periwinkle plant (Vinca rosea).

Description

Physical properties

  • White or yellow water soluble powder.

Storage requirements

  • Keep refrigerated.
  • Protect from light.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Asparaginase
  • May cause additive bone marrow suppression.

Cisplatin or Paclitaxel

  • May increase neurotoxicity.

Digoxin

  • Serum levels and effects of digoxin   Digoxin  may be decreased by vincristine.

Calcium channel-blockers

  • May increase intracellular vincristine by inhibiting the drug's outflow from the cell.

with diagnostic tests

  • Increases blood and urine concentrations of uric acid.
  • Monitor CBC with every treatment.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Fischer D S, Knobf M Tet al(2003)The Cancer Chemotherapy Handbook.6th edn. Philadelphia, PA, Mosby. pp 234-236.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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