ISSN 2398-2950      

Vincristine

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Introduction

Name

  • Vincristine sulfate.

Class of drug

  • Vinca alkaloid antineoplastic agent, derived from the periwinkle plant (Vinca rosea).

Description

Physical properties

  • White or yellow water soluble powder.

Storage requirements

  • Keep refrigerated.
  • Protect from light.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Asparaginase

  • May cause additive bone marrow suppression.

Cisplatin or Paclitaxel

  • May increase neurotoxicity.

Digoxin

  • Serum levels and effects of digoxin Digoxin  may be decreased by vincristine.

Calcium channel-blockers

  • May increase intracellular vincristine by inhibiting the drug's outflow from the cell.

with diagnostic tests

  • Increases blood and urine concentrations of uric acid.
  • Monitor CBC with every treatment.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. BSAVA, UK.
  • Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook. 6th edn. Mosby, USA. pp 234-236.
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