Felis ISSN 2398-2950

Vinblastine

Contributor(s): William Brewer Jr, Laura Garrett

Introduction

Class of drug

  • Vinca alkaloid antineoplastic agent derived from the periwinkle plant (Vinca rosea)

Description

Chemical name

  • Vinblastine sulfate.

Molecular formula

  • C46H58N4O9.H2SO4

Molecular weight

  • 909.06

Physical properties

  • 1 mg/ml clear solution or white to slightly yellow lyophilized powder for reconstitution.

Storage requirements

  • Keep refrigerated, Protect from light.
  • Powder stable for one month at room temperature.
  • Reconstituted powder stable for one month in refrigerator.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Enhances intracellular accumulation of methotrexate   Methotrexate  .

with diagnostic tests

  • May significantly increase blood and urine uric acid levels.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Chabner B A & Longo D L (1996) Cancer Chemotherapy and Biotherapy: Principles and practice, 2nd ed. Philadelphia, PA: Lippincott-Raven; 264-274.

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