ISSN 2398-2950      

Verapamil

ffelis

Introduction

Name

  • Verapamil.

Class of drug

  • Calcium channel blocker.
  • Class IV antidysrhythmic agent.

Description

Chemical name

  • Benzenacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethy]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)monohydrochloride.

Molecular formula

  • C27H38N2O4.HCl.

Molecular weight

  • 491.

Physical properties

  • Crystalline powder with bitter taste.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Primarily used to control supraventricular tachycardias, sustained and paroxysmal ventricular tachycardias particularly in cases of hypertrophic cardiomyopathy , and the heart rate in dogs with atrial fibrillation as an adjunct to digoxin .

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Beta-adrenergic blockers, eg propranolol

  • Propranolol Propranolol may be additive negative inotropic and chronotropic effects.

Calcium salts or vitamin D

  • The activity of verapamil may be adversely affected.

Cardiac glycosides

  • Digoxin Digoxin  and digitoxin Digitoxin  plasma concentrations are increased by verapamil Verapamil.
  • Monitor serum levels if used with verapamil.

Non-depolarizing muscle relaxants

  • Effects enhanced by verapamil.

Cimetidine

  • Cimetidine Cimetidine inhibits the metabolism of verapamil increasing plasma concentrations.

Theophylline

  • Verapamil enhances the effect of theophylline Theophylline possibly leading to toxicity.

Protein bound agents, eg warfarin

  • Verapamil may displace these Warfarin from plasma proteins.

Vincristine

  • Verapamil may increase intracellular vincristine Vincristine  levels by inhibiting the drugs outflow from the cell.

with diagnostic tests

  • Raised liver enzymes (in humans).

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. 
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!