Felis ISSN 2398-2950

Trilostane

Synonym(s): WIN 24, 540, Modrenal

Contributor(s): Francesca Gordon, Ian Ramsey

Introduction

Name

  • Trilostane.

Class of drug

  • Adrenocortical suppressant (inhibits the 3-beta-hydroxysteroid dehydrogenase isomerase enzyme system).

Description

Chemical name

  • (4-alpha, 5-alpha, 17-beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile.

Molecular formula

  • C20H27NO3.

Molecular weight

  • 329.44.

Physical properties

  • White or almost white crystalline powder.

Storage requirements

  • Store in a dry place.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Do not use with other drugs suppressing adrenal function, eg mitotane   Mitotane  .

Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Boag A K, Neiger R & Church D B (2004)Trilostane treatment of bilateral adrenal enlargement and excessive sex steroid hormone production in a cat.JSAP45(5), 263-266 PubMed.
  • Neiger R, Witt A L, Noble A & German A J (2004)Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats.J Vet Intern Med18(2), 160-164 PubMed.
  • Skelly B J, Petrus D & Nicholls P K (2003)Use of trilostane for the treatment of pituitary-dependent hyperadrenocorticism in a cat.JSAP44(6), 269-272 PubMed.

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