Felis ISSN 2398-2950

Topiramate

Contributor(s): Laurent Garosi, Mark Lowrie

Introduction

Name

  • Topiramate.

Class of drug

  • Sulphamate-substituted monosaccharide.

Description

Chemical name

  • 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate 

Uses

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Indications

  • Mono- or adjunctive anti-epileptic drug.
  • Treatment and prevention of migraine.
  • Treatment of neuropathic pain.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Relatively low potential for clinically relevant interactions with other medication.

 

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • Plessas I N, Volk H A, Rusbridge C et al (2015) Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia. Vet Rec 177, 288 PubMed.
  • Kiviranta A M, Laitinen-Vapaavuori O, Hielm-Bjorkman A et al (2013) Topiramate as an add-on antiepileptic drug in treating refractory canine idiopathic epilepsy. J Small Anim Pract 54, 512-520 PubMed.
  • Plessas I N, Volk H A, Kenny P J (2013) Migraine-like episodic pain behaviour in a dog: can dogs suffer from migraines? J Vet Intern Med 27, 1034-1040 PubMed.
  • Streeter A J, Stahle  PL, Holland M L et al (1995) Pharmacokinetics and bioavailability of topiramate in the beagle dog.  Drug Metab Dispos 23, 90-93 PubMed.

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